Welcome to our guide on Ozempic storage!

Ozempic (semaglutide) is an injectable medication specifically designed for type 2 diabetes that helps lower blood sugar levels and potentially offers weight-loss properties as well.

Today, let’s address an important yet often overlooked concern about Ozempic: its storage and refrigeration requirements.

Semaglutide, the active drug inside your Ozempic pens, is very sensitive to temperatures and requires meticulous care and temperature control to ensure it stays as effective as it should.

We’ll walk you through the essential steps and tips for storing your Ozempic safely and securely. From refrigeration at home to travel tips, we've got you covered with a comprehensive list of questions and answers about how to store Ozempic.

Ozempic travel coolers for storing ozempic cool while traveling

Related article: How to Travel With Ozempic: Travel Cases & Flying Tips!

Get the full picture by watching the video below!

Does Ozempic Need to Be Refrigerated?

Yes, Ozempic does indeed need to be refrigerated to maintain its potency and effectiveness. However, the good news is that there's a bit of flexibility in its storage requirements. Your Ozempic pens can actually remain safely out of the fridge for up to 56 days, providing a reasonable window of time for use. But let's delve into the specifics to understand exactly what this entails.

Related articleIs Ozempic the same as Insulin? What’s the difference?

Ozempic storage instructions

According to Novo Nordisk, Ozempic manufacturer, here’s how you should store your Ozempic pens:

  • Unopened Ozempic pens: Store your unopened Ozempic pens in the refrigerator at temperatures between 36°F and 46°F (2°C - 8°C).
  • After opening: Once you've used your Ozempic pen for the first time, you have two options. You can either keep it at room temperature, ensuring it stays below 86°F (30°C), or return it to the fridge. Regardless of your choice, it must be used within 56 days maximum!

Related article: How to Store Zepbound, The New Weight-Loss Injection?

What happens if Ozempic is not refrigerated?

When Ozempic is not refrigerated, the stability of its active ingredient (semaglutide) may be compromised. Refrigeration helps extend the shelf life of biological drugs like Ozempic by slowing down chemical reactions that can lead to degradation.

At a biological level, when semaglutide isn't refrigerated, several things can happen:

  • Protein instability. Semaglutide is a peptide-based medication, and peptides are prone to degradation when exposed to higher temperatures. Refrigeration helps maintain the stability of the protein structure, preventing it from unfolding or breaking down. 
  • Chemical degradation. Higher temperatures can accelerate chemical reactions within the medication, leading to degradation of semaglutide. This degradation can reduce the potency of Ozempic, impacting its ability to effectively lower blood sugar levels. 
  • Microbial growth. Warmer temperatures provide an ideal environment for microbial growth, which can contaminate Ozempic and render it unsafe for use. Refrigeration helps inhibit the growth of microorganisms, helping to maintain the sterility your injections. 
  • Loss of efficacy. Ultimately, if semaglutide is not refrigerated properly, iyour Ozempic pens may lose partial or total efficacy, which could lead to less effective blood sugar control and increase the risk of complications associated with diabetes.

In summary, Ozempic refrigeration is essential to preserve its stability, potency, and safety and has a direct impact on your diabetes treatment and, ultimately, your health!

How long can Ozempic be out of the fridge? 

Ozempic can be left out of the fridge for up to 56 days. However, beyond this timeframe, it should be discarded. Laboratory tests indicate that Ozempic loses effectiveness after 56 days, diminishing its ability to regulate blood sugar levels. 

But that’s not it! Even when unrefrigerated, Ozempic should always be protected from the heat. Exposure to temperatures above 86°F (30°C) can compromise its potency, rendering it ineffective.

Therefore, those living in or traveling to places where temperature may get higher than 86°F (30°C) should use a medical-grade cooler to transport their Ozempic pens.

Related articleHow to Use an Ozempic Pen?

FAQs About Ozempic Storage & Refrigeration 

Alright, we've covered the basics about Ozempic refrigeration, but let's get down to the nitty-gritty. Here are some common questions you might have about storing and refrigerating Ozempic, along with practical answers and our best tips to help you maintain the full potency of your semaglutide injections.

Related article: Does Insulin Need to be Refrigerated? How to Store it Properly?

How long is Ozempic good for? 

Ozempic pens stored properly in the fridge are good until their expiration dates, generally indicated on the pen itself and the carton box.

Once opened or unrefrigerated, Ozempic pens are good for 56 days only. Beyond this period, they should be discarded, even if there’s still medicine inside!

If exposed to temperatures above 86°F (30°C), Ozempic pens should not be used, regarless of their expiration date and the 56 days window. 

How long does Ozempic last in the fridge?

When properly stored in the fridge at temperatures between 36°F and 46°F (2°C - 8°C), unopened Ozempic pens last until their expiration dates.

After opening, Ozempic pens last for up to 56 days, regardless of whether they've been kept in the fridge or stored at room temperature. 

Any exposure to temperatures exceeding 86°F (30°C) compromises the effectiveness of Ozempic, even if they’re re-refrigerated afterwards.

How long is Ozempic good for after opening?

After opening, Ozempic is good for up to 56 days when stored at room temperature (below 86°F or 30°C) or in the fridge.

After this period, semaglutide, its active ingredient, starts to lose its effectiveness and isn’t safe for use anymore.

Related article: Does Wegovy Need to be Refrigerated? How to Store Your Pens?

What happens if you use Ozempic after 56 days?

Using Ozempic beyond the recommended 56-day period is not safe. It can lead to reduced effectiveness in controlling blood sugar levels. Extended use of Ozempic beyond this timeframe may result in inadequate management of diabetes and potentially serious health complications. 

Always keep track of this expiration period and never use an Ozempic pen that’s been out of the fridge or open for more than 56 days. Dispose of it after 56 days, even if there’s still medicine inside, and get a new one from the refrigerator.

Related article: Wegovy Vs. Ozempic: Comparing 2 Semaglutide Injections.

What To Do If You Forgot To Refrigerate Ozempic?

If you forgot to refrigerate Ozempic, the first thing to do is not to panic. Slip-ups can happen and do happen to everyone relying on refrigerated drugs. And remember, Ozempic can be kept out of the fridge for up to 56 days.

Returning Ozempic to the fridge as soon as possible will help maintain its stability and effectiveness. For instance, if you accidentally left your Ozempic pen on the kitchen counter for a few hours, don't fret. Just put it back in the fridge, and it should still be good to use within the 56-day limit.

Can Ozempic be stored at room temperature? 

Yes, Ozempic can be stored at room temperature for up to 56 days. Storing Ozempic at room temperature offers flexibility, especially for those on the go or traveling.

In this context, room temperature refers to a range between 59°F to 86°F (15°C to 30°C).

For instance, imagine you're traveling to a destination where refrigeration isn't readily available. You can store your Ozempic pen in your luggage or carry-on bag, knowing that as long as the temperature stays below 86°F (30°C), your injector pens will be safe to use throughout your trip.

How long is Ozempic stable at room temperature?

Ozempic is stable at room temperature for 56 days after the first use or being out of the refrigerator.

This means that if you've taken your first dose from a new pen, you have approximately two months to finish it before it needs to be discarded. It's essential to keep track of when you started using the pen to ensure you don't exceed the recommended timeframe.

For instance, if you started using a new Ozempic pen on April 1st, you should dispose of it by May 26th, even if there's still medication left inside!

What if Ozempic was left out overnight?  

If Ozempic was accidentally left out overnight, its safety for use depends on the temperature.

If the room temperature remained below 86°F (30°C), your Ozempic is still good for use. But as the cold chain has been broken, the pen must be used within 56 days, regarless of whether you place it back in the fridge or decide to keep at room temperature.

However, if there's any doubt or if the temperature was exceptionally high, it's safer to discard this Ozempic pen and start with a new pen from the refrigerator.

Can you put Ozempic back in the fridge?

Yes, you can put Ozempic back in the fridge after it has been at room temperature (always below 86°F (30°C)!). 

For example, let's say you took your Ozempic pen out of the fridge in the morning to inject your dose and left it on the kitchen counter throughout the day. You can return your Ozempic pen to the fridge in the evening. However, it must be used within 56 days, as placing it back in the fridge won't extend this 56-day period! 

Store ozempic refrigerated during travels


Can You Inject Ozempic Cold?

Yes, you can inject cold Ozempic from the fridge. However, injecting cold medication might cause discomfort or increased pain during the injection.

To make the injection more comfortable, you can let the Ozempic pen sit at room temperature for a few minutes before administering the dose. This can help reduce any discomfort associated with injecting cold medication.

Related article: 10 Tips That Work to Inject Insulin Without Pain! 

What Happens if Ozempic Freezes?

Just like InsulinVictoza, and practically any other drugs, Ozempic can’t be frozen. Ozempic is an aqueous solution, meaning that semaglutide, its active ingredient, is dissolved in water.

Just like water, Ozempic freezes at 32°F (0°C) and becomes solid. Once frozen, the solution structure breaks down irreversibly, rendering it ineffective. Even if it thaws afterward, frozen Ozempic remains unsafe for use. In such cases, you must discard the affected pen immediately and replace it with a new one.  

Does Ozempic expire?

Yes, like all medications, Ozempic expires. Each Ozempic pen comes with an expiration date printed on the pen itself and on the packaging. Generally, the expiration date occurs about a year from the purchase date. Awlays check this date before using Ozempic to ensure your pen hasn’t expired.

But that’s not all! Really, Ozempic has two expiration dates. The “official” one labelled on the pen, and the one that naturally occurs 56 days after a pen has been out of the fridge. Therefore, you must keep track of these 2 expiration dates to ensure you’re not using expired Ozempic. 

Never use expired Ozempic. If your Ozempic has passed its expiration date, or has been out of the fridge for 56 days, dispose of it and get a new pen from the refrigerator or the pharmacy. 

Related article: Does insulin expire? How long is it good for?

What is Ozempic shelf life?

The shelf life of Ozempic refers to the duration during which it maintains its potency and effectiveness when stored under appropriate conditions

As mentioned above, unopened Ozempic pens stored in the refrigerator are good until their expiration dates labelled on the pen or packaging. Once opened, Ozempic shelf life is limited to 56 days as long as they are kept at room temperature (below 86°F or 30°C). 

What happens if Ozempic gets hot? 

If Ozempic gets hot, its effectiveness may be compromised and the semaglutide inside may not work as it should.

Exposing Ozempic to high temperatures, especially above 86°F (30°C) and even briefly, can cause the medication to quickly degrade, reducing effectiveness in managing blood sugar levels. For instance, storing Ozempic near heat sources like radiators or ovens can subject it to temperatures beyond the recommended range, jeopardizing its therapeutic benefits.

What to do if you left Ozempic in a hot car?

If you accidentally left Ozempic in a hot car or exposed it to high temperatures, it’s probably causing your medication to go bad.

Check for any visible changes in the medication, such as discoloration or cloudiness, which may indicate degradation.

If there are any doubts about its integrity, it's safer to dispose of the pen and obtain a new one from the refrigerator. Avoid storing your medications in vehicles, especially during hot weather, to prevent exposure to extreme temperatures and ensure their safety for use.

Related article: Zepbound, Mounjaro, Wegovy, Ozempic: What’s the Difference?

Does Ozempic go Bad? 

Yes, Ozempic can go bad if not stored properly, exposed to heat, left unrefrigerated for more than 56 days, or if it's used beyond its expiration date. 

Related article: Can Insulin go bad? How to tell and what to do if it has?

How to tell if Ozempic has gone bad? 

Ozempic (semaglutide) is a clear and colorless liquid. If you notice any solid elements inside your pen, like strings or particles, if it has changed color or looks different than usual, these may be sign your Ozempic has gone bad.

Unusually high blood glucose levels can also warn you that your injection isn’t working as it should, so it might have expired.

In case of doubt, stop using the pen, get a new one from the fridge, and ask for your doctor or pharmacist’s advice.

What happens if you inject bad or expired Ozempic?

Injecting expired Ozempic won't poison you, but it simply won't work as intended. This could lead to diabetes-related complications because of high blood sugar levels, such as hyperglycemia

If you have inadvertently injected expired Ozempic or are unsure about its potency, consult your healthcare provider for guidance. 

How to Store Ozempic While Traveling

When traveling with Ozempic, temperature control and cold storage are keys! Here are some tips for keeping your Ozempic cool and safe during your travels:

Room-temperature storage for short trips

If your travel duration is within the 56-day window, you can keep your Ozempic pens at room temperature, protected from excessive heat and direct sunlight.

Invest in a portable cooler or insulated bag to carry your Ozempic pens, like the ones from 4AllFamily.

Ozempic travel storage case refrigerated

Refrigerated transportation beyond 56 days

If your travel extends beyond the 56-day limit, you must transport your Ozempic pens refrigerated. In that case, we recommend using one of our medical-grade travel refrigerators!

Regardless of the duration of your trip, planning ahead and taking the necessary precautions will help keep your Ozempic pens cool while traveling!

Related article: How to Keep Ozempic Cool While Traveling!

How to store Ozempic while traveling

4AllFamily's Travel Coolers have been specially designed for temperature-sensitive medicines like Ozempic. 

We’d Love to Hear From You!

Are you on Ozempic? Have you had any issue with storage and refrigeration of your pens? Don’t hesitate to share your stories and questions below!

Last Updated On May 2, 2024

July 25, 2021


4AllFamily Customer Care Team said:

Dear Zinah,
Thank you for your interesting questions.
1. If the Ozempic pens were wrapped with ice during transportation that lasted only 1 hour, they have most probably not reach room temperature and were under refrigeration conditions. So I would say that if you’ve put them in your fridge once at home, you can consider they’ve been refrigerated the whole time.
2. We do not recommend transporting refrigerated medication with ice, mainly for two reasons. The first one is that direct contact with ice could freeze your Ozempic, which is not good. The second one is that this is not a reliable refrigeration method as you never know how quick the temp. will rise.
Most people chose to get a real, convenient, and reliable travel cooler like the ones we offer here: https://4allfamily.com
Please don’t hesitate if you have other doubts or questions!
Safe trips!
4AllFamily Customer Care Team

Zinah said:

I bought few ozempic pens fron the pharmacy , they rapped it with ice pack and I drove home for 1 hour.
My questions are
1- is that one hour concider as unrefregerated and should be used in 56 days? As i bout few pens and should use for next 6 months.
2- I am traveling with long flights , do u think that rapping with ice is enough to keep them as refrigerated?
Thank u

4AllFamily Customer Care Team said:

Dear Romi,
You’re allowed to take injectable medications such as Ozempic through airport security. When they need to be refrigerated, you can carry them in insulated bags with ice packs or, preferably, reliable travel coolers such as the one we offer here: https://4allfamily.com/collections/all.
All of our coolers and TSA-approved.
Additionally, here’s an interesting article about traveling with refrigerated drugs like Ozempic: https://4allfamily.com/blogs/traveling-with-medicines/how-to-travel-with-refrigerated-medication
Wishing you safe and happy travels,
4AllFamily Customer Care Team

Romi Elnagar said:

How do you get Ozempic, with an icepack or other means of refrigeration, past airport security?

4AllFamily Customer Care Team said:

Dear Señora Dora del Pilar,

Seguramente, las bolsas frías están aquí para mantener el Ozempic frío durante el envío a su domicilio. No es necesario guardarlas una vez que haya colocado el Ozempic en el frigorífico.

Un saludo,
4AlllFamily Customer Care Team


El día de hoy recibí el medicamento pero junto a el me ENTREGARON DOS BOLSAS MUY FRIAS LAS CUALES no se para que son??? Espero respuesta muchas gracias

4AllFamily Customer Care Team said:

Dear Mandy,
You should not use a pierced pen of Ozempic. Damaged pens aren’t safe for use, and even more so if they’ve been emerged in water. The water may contain bacteria or other harmful substances that can contaminate your pen and lead to infection or other health issues.
We would definitely recommend not using it or asking for your pharmacist or doctor’s advice first.
Warm regards,
4AllFamily Customer Care Team

Mandy said:

If my pierced pen was emerged in water is it safe to use? My lovely husband allowed the pen to slip down as he grabbed cans out of the ice chest. Ice melted…pen landed in water. Please advise

Mandy said:

If my pierced pen was emerged in water is it safe to use? My lovely husband allowed the pen to slip down as he grabbed cans out of the ice chest. Ice melted…pen landed in water. Please advise

4AllFamily Customer Care Team said:

Hi Riham,
I’m sorry to hear about that. Unfortunately, according to Novo Nordisk, the manufacturer of Ozempic, you should not use Ozempic that has frozen, even if it has thawed afterward. It is not safe for use anymore.
Have you tried reaching out to Novo Nordisk? Maybe they can help and send you a new batch? It’s worth the try…
Let us know if it works,
Warm regards,
4AllFamily Customer Care Team

4AllFamily Customer Care Team said:

Hi Barbara,
Sorry to hear about you feeling so bad lately. Unfortunately, we can not help you or give medical advice here. We can only recommend you talk to your doctor about your recent symptoms and seek for his advise.
We hope you’ll feel better soon,
Warm regards,
4AllFamily Customer Care Team

Riham said:

I freezed ozemptic due to receiving bad and unclear instructions.

I put all my savings to buy it and you can imagin for how long I have been dreaming of the day to start using it. It really killed me to know that I need to through it.

Is there any chance that I might lose some weight if I use it (frozen)?

What are the side effects if I do?

It is impossible for me to afford buying a new one.

Barbara Dunlap said:

I took ozempic insulin last Fri. Mng. About midnight I had chills and felt awful. Next day woke up nauseated, throwing up. Headache. It came and went every few hours.it eased up with every passing day. But every few hours I was slightly nauseated.. it lasted for 7 days. I am afraid to take to take another dose as I think it was the ozempic. Been taking it close to a yr with no effects.

4AllFamily Customer Care Team said:

Hi Alice,
Since no liquid came out, I believe you haven’t lost any medication. Have you managed to use your pen correctly next? We’ve recently published a new article about How to use an Ozempic pen. You can read it here: https://4allfamily.com/blogs/diabetes/how-to-use-an-ozempic-pen . I hope that’s helpful!
Best of luck,
4AllFamily Customer Care Team


I was unfamiliar with the pen and didn’t take the covers off the needle. I did it a few times and no liquid came out so I thought it was ok. Have I lost some of the medication ?

4AllFamily Customer Care Team said:

Hi Mary,
Once Ozempic has been unrefrigerated, it stays effective for 56 days max, whether or not you have put it back in the fridge. Your pens are still safe to use, but within 56 days only.
I hope I’ve answered your question,
Best regards,
4AllFamily Customer Care Team

Mary said:

Is my pen still effective if it is received from the pharmacy refrigerated then left unrefrigerated before use? I left them unrefrigerated for a couple of weeks then returned to the refrigerator,

4AllFamily Customer Care Team said:

Hi Caitlin,
Unfortunately, there is no way to tell if your Ozempic was frozen or not. We would recommend not using them because frozen Ozempic may have lost its properties and become inefficient.
If you still decide to use them, make sure to keep a close watch on your blood sugar. Unusually high blood sugar levels may be a sign your Ozempic was frozen…In that case, throw them away and get new ones.
All the best,
4AllFamily Customer Care Team

4AllFamily Customer Care Team said:

Hi Mayumi,
Yes, your pens are still good for use, but you should use them within 56 days max. Once it has reached room temperature, Ozempic is only goof for 56 days, even if it has been put back in the fridge.
All the best,
4AllFamily Customer Care Team

Caitlin Boulay said:

My Ozempic order was delivered and left in my community mailbox for 2 nights. Both nights it dropped to below 0°, is there a way to tell it was frozen?

Mayumi said:

Hi ,
I am a provider and my pt went out of town and got back on 11/20 , family didn’t realized that ozempic needs to be in the fridge when delivered on 11/11 ,, now all of them are in the fridge ,, if solution is clear and no Particle and when pens are in room temperature approximately 9 days ,, this is still good to use right ?

4AllFamily Customer Care Team said:

Hi Margaret,
You can find the expiration date either on the carton box or the Ozempic pen itself.
Ozempic pens can only stay out of the fridge for a maximum of 56 days, even if they have not been used or open yet. The medicine might still look clear and have no particles in it, but that does not mean it hasn’t lost efficiency. We’d definitely advice sticking to the manufacturer’s instructions and not using this pen.
Best regards,

Margaret said:

If a pen has been left unopened/unused in average home temp (~69 degrees) for longer than 56 days, can it still be used. Medicine is still clear with no particles in it. Also, where on the packaging can you find the expiration date?

4AllFamily Customer Care Team said:

Hi Melanie,
Thanks for your comment. No, keeping your Ozempic in the fridge after opening won’t make it less effective. But keep in mind that it won’t extend its expiration date, and you should use your pen within 56 days max.
All the best,
4AllFamily Customer Care Team

Melanie said:

If I keep my
Ozempic in the fridge even after opening, is it less effective?

4AllFamily Customer Care Team said:

Hi Nathalie,
It’s ok, especially is your house was cool. Ozempic is good for up to 56 days once out of the fridge. Just make sure to use this pen first and within the 56 following days!
Best regards,
4AllFamily Customer Team

4AllFamily Customer Care Team said:

Hi Kimberley,
It’s quite unlikely that Ozempic that has gotten warm makes you sick. Most of the time, if the medication has reached high temperatures, it deteriorates and loses efficiency but should not make you vomit or have diarrhea. However, if in doubt, throw your pen away and get a new one from te pharmacy. If vomiting and diarrhea don’t stop, seek medical attention.
I hope you get better soon,
4AllFamily Customer Care Team

Natalie said:

Hi I forgot to put my ozempic in the refrigerator when I got it, I remembered the next morning, would this be considered bad? I put it in the refrigerator once I remember (off refrigerator for about 15 hrs). The house was quite cool.

Kimberly said:

My new prescription was in a hot car for about 4 hours (someone picked it up for me) 24 hours after I used it I have had severe vomiting and diarrhea. Could I just have a virus or is it the Ozempic?

4AllFamily Customer Care Team said:

Hi Red,
Unfortunately, your pen is not safe for use anymore. Ozempic that has frozen, even temporarily, loses its efficiency even if it has thawed afterwards. We do recommend you throw away this pen and get a new one.
Best regards,
4AllFamily Customer Team

Red said:

My pen was frozen by accident for 24 hours. Holiday weekend. Can it be used? What happens if I use it? Thankyou.

4AllFamily Customer Care Team said:

Hi Nathalie,
Yes, you can still use your Ozempic within 56 days. Ozempic can be stored out of the fridge during 56 days max. During that time, it should never be exposed to temperatures above 86°F (30°C).
All the best,
4AllFamily Customer Care Team

4Allfamily Customer Team said:

Hi Abeer Hamzeh,
Ozempic freezes at 32°F (0°C). Once frozen, the solution breaks down. It does not regain its original efficiency. Once it has frozen, Ozempic is not safe for use anymore, even if it has thawed afterward. If your pens has spent a whole day in a freezer, it’s probably not safe for use anymore.
All the best,
4AllFamily Customer Care Team

4AllFamily Customer Care Team said:

Hi Kim,
Ozempic can be left out of the fridge for up to 56 days. During that time, If exposed to temperatures above 86°F (30°C) for extended periods of time, Ozempic pens are not safe for use anymore and should also be disposed of.
So, about the two days without refrigeration, it’s fine and you can use your pen within 56 days max.
Regarding the overnight in a hot car, it depends what was the temperature inside. If it was above 86°F (30°C), you should be careful. Below that temperature, it’s fine to use.
I hope I have answered your question,
All the best,
4AllFamily Customer Team

Natalie said:

I bought ozempic and was not told to keep it in the refrigerator. It has been unrefridgerated for almost 11 hours, exposed to temperature less than 20° can I still use it?

Abeer Hamzeh said:

What happens if ozempic is accidentally kept in freezer for than one day?? Can I still use it??

Kim said:

I need to know if my ozempic is usable. I didn’t know it had to be refrigerated. It’s been two days without refrigeration and in a hot car overnight. All pharmacies within 50 miles are closed. Help!!

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The information presented in this article and its comment section is for informational purposes only and is not intended as a replacement for professional medical advice. Always consult with a qualified healthcare provider for any medical concerns or questions you may have.