Humira is a prescription medicine used for the symptomatic treatments of various inflammatory diseases such as rheumatoid arthritis (RA), Crohn’s disease (CD), and others. It’s one of the best-selling drugs in the World and comes in the form of self-injectable pens or prefilled syringes.

Like most injectable liquid medicines, Humira is sensitive to high temperatures and temperature changes. It requires refrigeration when not in use and needs to be protected from the heat once open. Because of these specific storage requirements, traveling with Humira can be challenging. How to make sure your Humira pen stays refrigerated and protected from the outside heat while you’re traveling?

4AllFamily travel coolers for medical use

Related article: 8 Great tips for traveling with Psoriatic and Rheumatoid Arthritis

How to travel with Humira?

Traveling with chronic diseases like rheumatoid arthritis or Crohn's disease raises a great number of questions. Keeping Humira cool is a big concern for people traveling with this medicine. Another one is about documentation: what papers do you need to travel nationally or internationally with Humira?

How to keep Humira cool while traveling?

Like similar injectable medications used for the treatment of rheumatoid arthritis and Crohn’s disease such as Enbrel, Actemra, Cimzia, Orencia, Taltz, Kevzara, Cosentyx, or Simponi, Humira (Adalimumab) is sensitive to temperature and light. It quickly deteriorates and loses efficiency when exposed to high temperatures or direct light. 

Traveling with refrigerated medications requires carefulness and organization. Whether you’re flying, taking a cruise ship, road tripping through the States, or spending a day at the beach, your life-saving medicine needs to stay cool, so it does not spoil.

According to Abbvie, Humira’s manufacturer, “Humira needs to be stored in a refrigerator ((2°C-8°C/36°F-46°F) in its original container and protected from the light until it’s used (…). It may be stored at room temperature up to a maximum of 25°C/77°F for a period of up to 14 days, with protection from light.”

To make sure your Humira pen is safe and does not deteriorate while traveling, you must keep it refrigerated (when not in use) or protected from the heat (once open). If you're living in or traveling to places where the outside temperatures are often above 25°C/77°F, you need to use a medical travel cooler.

Here are a few pieces of advice to keep Humira cool and protected from the light in all situations:

  • Use a medical cooler if needed
  • Avoid direct sunlight
  • Always keep your Humira pen in the shade
  • Leave it at home if you're going to the beach or other sunny and warm places
  • Never leave your Humira pen in the car
  • Keep it far away from heat sources such as the hot plate, burner, oven, fireplace, barbecue, etc.…

Caution: Humira pens or syringes that have not been stored according to the above instructions aren't safe for use anymore.

Related article: Humira storage: How long can Humira be out of the fridge without risks?

How to travel internationally with Humira?

Another big concern for people traveling with chronic diseases is how to travel internationally with their medications. When you live with diseases like diabetes, asthma, chronic migraines, rheumatoid arthritis, Crohn’s disease, or others there’s no way you would leave your home country without your life-saving medications.

But how to cross borders with your meds? What documents do you need to go through airport security and customs checkpoints? Will your travel insurance cover the costs of an unfortunate health-related event while in Thailand? 

While Humira is a drug that's sold in most countries around the globe, you still have some paperwork to plan before flying off! Here’s a list of the documentation you might be required to show when traveling internationally with medications like Humira:

  • A doctor’s letter
  • Your medical prescriptions
  • A document from your pharmacy
  • The original containers and labels of the medicine
  • Your medical health card

Related article: Arthritis Travel Insurance: How to Make Sure You're Covered?

Can you fly with Humira?

Can you fly with Humira?

Yes, you can fly with your Humira pens and prefilled syringes, as well as all the necessary medical supplies associated with their use (unused and used needles, alcohol swabs, syringes, etc.). Medications are not subject to the TSA’s 3-1-1 rule for liquids, gels, and aerosols. The Transportation Security Administration expressly states so on its website.

When traveling by plane, always pack Humira and other medicines and medical supplies in your carry-on. Checked luggage sometimes gets lost. Besides, the atmosphere and temperature conditions in the hold aren't stable and your medicine could get damaged during the flight.

To speed up and smooth the airport security screening process, you may want to download, print, and fill out a TSA medical notification card, but it’s no obligation.

Be aware that due to pressure changes during take-off and landing, air bubbles can appear in your Humira pens or prefilled syringes. It's no problem, but you must prime your pen or syringes before proceeding to the next injection to get rid of all the air inside. If not, you would be injecting air instead of medicine, which could lead to a lack of medicine and the correlated side effects.

Related article: Flying with Arthritis, How to Prepare for Long-Haul Flights?

Can Humira go through airport x-ray machines?

Yes. Humira can safely go through airport x-ray machines. But if you’re not comfortable with putting your medication in the x-ray machines, note that you always have the right to request a hand-screening of your luggage instead.

Related article: 10 Great Anti-inflammatory Snacks for Rheumatoid Arthritis.

4AllFamily Humira Travel case to keep Humira cool

Because of its high sensitivity to temperatures and its rigorous storage instructions, traveling with Humira can be stressful. How to make sure your medicine is safe and kept at the right temperature at any time and in any situation?

What if you're on an off-the-beaten-track hiking route and have no electricity to refrigerate your Humira pen? What if you're going on a 4-week road trip across Canada? Or what if you need to take your refrigerated pen of Humira on a 14-hours flight?

4AllFamily Humira travel cooler

4AllFamily specializes in medical-grade travel coolers for people living with chronic diseases and depending on refrigerated medications. Our product line is made to fit everyone’s needs from a few hours of protection from the outside heat to several days of constant refrigeration.

Travel Coolers for refrigerated drugs, Humira, Enbrel, Insulin, Ozempic, Mounjaro, Saxenda, Wegovy, Epipen


Depending on your needs and lifestyle, our different coolers can function with simple biogel freeze packs or USB power. They're pluggable into any USB-compatible power source such as household power, car cigarette lighters, travel-size power banks, or portable solar panels.

All of our medicine travel coolers are TSA-approved so you can board the plane with your refrigerated medicines. 

Related article: 10 Useful tips for traveling with Crohn’s Disease and IBD

We hope this article has answered all your questions about traveling with Humira. If not, please do not hesitate to ask in the comment sections. We’d be happy to help you out!

April 25, 2022


4AllFamily Customer Service said:

Hi Lanie,
Thank you for reaching out with your questions regarding keeping your Humira cool during your travels. The duration for which our medical coolers can keep your Humira pens cool varies based on the model, as well as the as ambient temperature and the number of pens you need to carry. Additionally, whether you require refrigeration or simply room-temperature storage also plays a role.

For personalized guidance, I recommend reaching out to our customer service team. They are equipped to assist you in selecting the best cooler for you.
Safe travels, and feel free to contact us for any further assistance!
Warm regards,

Lanie broadway said:

I need to travel internationally my journey from leaving home to waiting at the airport then including my flight time will be about 15 hours. How long will your containers keep my HUMIRA cool for ?
Also I like many others who have asked questions about extended stays needing 6-8 pens are only informed about containers that hold 3 or 4 injections? Do we need to buy multiple coolers?

4AllFamily Customer Care Team said:

Dear Jaime,
Our largest coolers, including the Big Nomad and the Explorer, can fit up to 4 Humira syringes, so you will need to purchase several units. Should you need any further help, please don’t hesitate to contact our customer care team at +1 508 921 0865 or on the live chat below.
Warm regards,
4AllFamily Customer Care

Jaime said:

Hi, I prefer to use the Humira syringes and am planning a trip where I will need to take 12 syringes with me. Would you be able to recommend a carry case that would work for holding 6-12 syringes? Thanks 😊

4AllFamily Customer Care Team said:

Dear Pat,
You can read more information about traveling with medication internationally in our article here:
To keep her Humira pens cool while traveling, I would suggest getting the Bid nomad cooling case, it can fit 4 Humira pens and keep them refrigerated for more than 30 hours:
Please don’t hesitate to contact our support team if you need any help,
Best regards,
4AllFamily Customer Care Team

Pat said:

My daughter is traveling abroad to Florence. How does she take 8 pens with her. ITA airlines. She has so much to carry as it is. What documents does she need to carry to travel with it? No one has the right answer. Thank You.

4AllFamily Customer Care Team said:

Hi Shi Milld,
We have a wide range of cooling solutions for people traveling with Humira pens, including:
- The Pionner and Voyager travel refrigerators: 3 Humira pens at fridge temperature
- The Explorer: 4 Humira pens at fridge temperature
- The Nomad coolers: 4 Humira pens in the big one and 1 pen in the medium size
- The Companion cooling bag: 2 Humira pens at room temperature.
Do not hesitate to contact our support team for further guidance,
Best regards,

Shi Milld said:

How many Humira pens can fit in the container?

4AllFamily Customer Care Team said:

Hi Laura,
Humira pens are fully labelled so you can travel with them out of their original box. The original packaging is especially helpful when traveling with vials of medicine or tablets for example.
As an extra measure, you can keep your Humira pens in our cooler and take the empty package box on your carry-on.
Safe travels!
4AllFamily Customer Care Team

Laura said:

A lot of what I have read states that Humira should be kept in it’s original packaging when traveling. Certainly that’s not possible while using your coolers. What is your recommendation?

4AllFamily Customer Care Team said:

Hi Katya,
Legally, you can’t travel with someone else’s prescription medications, whether nationally or internationally. You may be asked to show a copy of the medical prescription and it should be with your name on it. However, chances that you get a control are very low, and customs agents are generally compliant if you bring only small amounts of medicine… It depends on your destination country too.
Best regards,
4AllFamily Customer Care Team

Katya said:

Can I travel internationally with someone else’s Humira?

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The information presented in this article and its comment section is for informational purposes only and is not intended as a replacement for professional medical advice. Always consult with a qualified healthcare provider for any medical concerns or questions you may have.