Quick answer: Proper Praluent storage is essential for its effectiveness. It must be refrigerated between 36°F and 46°F (2°C - 8°C), but can be stored at room temperature (up to 77°F / 25°C) for up to 30 days. Use insulated or portable cooling solutions on trips longer than 30 days or to extreme temperatures.
If you're prescribed Praluent, understanding proper storage is essential to keep your cholesterol medication safe and effective at home and on the go.
Praluent (alirocumab) is a PCSK9 inhibitor used to lower LDL ("bad") cholesterol in patients with hypercholesterolemia who haven't responded well to diet or other treatments.
It's given by subcutaneous injection, usually once every two or four weeks, using convenient, pre-filled injector pens.
Like most biologic drugs, Praluent is sensitive to temperature. Improper storage can reduce its potency, which could affect your cholesterol levels and overall health.
In this guide, you'll learn everything you need to know about Praluent storage temperature, how long it can be unrefrigerated, and how to protect your pens while traveling, including the best Praluent travel kits to keep your meds cool.
Let's make sure your treatment stays safe wherever you are.
Related article: TSA: Traveling with Injectable Medications, Needles, and Syringes
Praluent storage temperature guidelines
According to Sanofi and Regeneron (Praluent's manufacturers), the medication must be stored in a refrigerator between 36°F and 46°F (2°C to 8°C).
This range preserves the stability and potency of the biologic drug. Praluent can only be stored outside this range for a limited amount of time before the medicine starts to degrade.
Why Does Praluent need to be refrigerated?
Praluent refrigeration is essential unless you're preparing to travel or inject it soon.
Like many injectable biologics (such as Insulin, Ozempic,,or Mounjaro), Praluent is fragile and temperature-sensitive.
Alirocumab, its active ingredient, is made from proteins that break down under heat, freezing, or direct sunlight. Refrigeration keeps these components stable and ensures the drug works as intended.
Without refrigeration, Praluent can break down, becoming ineffective or even harmful.
Following storage guidelines is essential for safe and effective cholesterol treatment.
💡 Pro tip: Always keep your medication in its original packaging in the fridge.
Related article: What Temperatures Should Refrigerated Drugs Be Kept At?
How long can Praluent be stored at room temperature?
If needed, Praluent can be stored at room temperature (up to 77°F or 25°C) for a maximum of 30 days, but only once.
After it's been out of the fridge:
❌ Do not return it to refrigeration.
❌ Do not freeze it.
❌ Do not expose it to heat or direct sunlight.
❌ Do not use it after the 30-day window ends.
Before injecting Praluent, check the following:
✅ It's been stored properly.
✅It hasn't been out of refrigeration longer than 30 days.
✅ It was never frozen.
✅ The solution is clear and colorless.
✅ The pen is within its expiration date.
When in doubt, ask your pharmacist or doctor. Never risk using compromised medication.
Traveling with Praluent: how to store it safely
If you're planning a trip and your next injection falls during travel, here's how to keep your Praluent safe:
Praluent storage for travel under 30 days
If your trip is 30 days or fewer and you'll stay in a cool environment, you can:
- Store Praluent at room temperature (up to 77°F / 25°C).
- Keep it protected from light (original packaging is best).
- Never leave it in hot places like a car or windowsill.
Traveling with Praluent to extreme temperatures (Above 77°F / 25°C)
If you're traveling somewhere hot, even for just a few days, you'll need to protect your Praluent pens from heat.
While Praluent can be stored at room temperature for up to 30 days, that's only true if it stays below 77°F (25°C)and out of direct sunlight.
In hotter environments, you must use an insulated medical cooling bag to prevent your medication from degrading.
Our reliable options for room-temperature control include:
✅ The Rambler Medical Cooling Case
Both these travel coolers can maintain a safe room temperature range of for many hours, even when the outside temperature hits 104°F / 40°C. They're compact, lightweight, discreet, and perfect for day trips or short flights.
💡 Pro Tip: Always store your cooler away from car dashboards or direct sun exposure. If you're on the move all day, consider bringing extra ice packs to extend cooling time.
Your Praluent travel kit for more than 30 days (or needing full refrigeration)
Planning a long trip and need to keep your Praluent refrigerated for more than 30 days? In that case, you'll need a travel fridge that can maintain stable refrigeration temps between 36°F - 46°F (2°C - 8°C).
Here are our top-rated Praluent travel kits solutions for traveling with refrigerated medications:
✅ The Voyager Portable Refrigerator for Medications
✅ The RxCoolers Mini Refrigerated Carrying Case
✅ The RxCoolers Max Advanced Mini Fridge
✅ The Explorer 3-in-1 Medical Travel Cooler
Summary: Your Praluent storage checklist
At home:
✔️ Store Praluent in the fridge (36°F - 46°F / 2°C - 8°C).
✔️ Never freeze or expose it to heat or light.
On the go:
✔️ You may store Praluent at room temperature (up to 77°F / 25°C) for 30 days max.
✔️ Use a cooler or travel fridge in hot weather or when traveling for over a month.
✔️ Always inspect the pen before injecting.
Whether you're managing your cholesterol at home or on the road, proper Praluent storage ensures your medication remains safe and effective.
From knowing the exact temperature range to choosing the right cooler for your travel needs, these tips help you stay on track with your treatment and protect your health.
When in doubt, always choose caution because storing Praluent correctly is a key part of your heart health journey.
Key Take Aways:
When storing your Praluent, be sure to keep these essential tips in mind:
🧊 Store it Right: Keep Praluent in the fridge at 36°F - 46°F. You can store at room temperature, but not for longer than 30 days.
🌡️ Mind the Temperature: If traveling in heat, use an insulated cooler like the Companion to stay under 77°F.
🌍 Travel Smart: For longer trips, pack a cooling solution like the Nomad or Voyager travel fridge to maintain safe temps.
🛡️ Protect Your Treatment: Always avoid freezing, overheating, or exposing Praluent to sunlight.
We'd Love to Hear From You!
💬 Have questions about Praluent storage at home or while traveling? We'd love to hear from you. You can ask them in the comments! Or share your tips and experiences! Your story might help someone else manage their medication with confidence.
📆 Article Update History:
✅ Updated and Medically Reviewed: April 23, 2025
Originally Published: May 10, 2023
